ChatGPT: Klotho is a protein that is involved in regulating several biological processes, including aging, cognition, and metabolism. It was first identified in mice in 1997, and subsequent research has shown that it is also present in humans.
One of the most well-known roles of Klotho is its ability to extend lifespan. Studies in mice have shown that overexpression of the Klotho gene can increase lifespan by up to 30%. It is believed that Klotho achieves this by suppressing insulin and insulin-like growth factor signaling, which are known to contribute to aging.
In addition to its effects on lifespan, Klotho is also involved in regulating several other processes in the body. These include:
- Cognition: Klotho has been shown to improve cognitive function and protect against age-related cognitive decline. It is believed to achieve this by promoting the growth and maintenance of neurons in the brain.
- Metabolism: Klotho has been shown to play a role in regulating glucose and lipid metabolism, and is believed to protect against insulin resistance and obesity.
- Cardiovascular health: Klotho has been shown to protect against cardiovascular disease by reducing inflammation and promoting the growth of blood vessels.
- Kidney function: Klotho is produced in the kidneys and has been shown to protect against kidney damage and chronic kidney disease.
- Anti-inflammatory effects: Klotho has been shown to have anti-inflammatory effects, which may help to protect against a variety of chronic diseases, including cancer, cardiovascular disease, and diabetes.
- Bone health: Klotho has been shown to play a role in regulating bone metabolism, and may help to protect against bone loss and osteoporosis.
- Skin health: Klotho has been shown to promote the production of collagen, which is important for maintaining healthy skin. This suggests that Klotho may have potential anti-aging effects on the skin.
- Neuroprotection: Klotho has been shown to protect against neuronal damage and cell death, which may have implications for the treatment of neurological diseases such as Alzheimer’s and Parkinson’s disease.
- Immune system regulation: Klotho has been shown to play a role in regulating the immune system, and may help to reduce inflammation and autoimmune responses.
- Cancer prevention: Some research has suggested that Klotho may have anti-cancer properties, and may help to prevent the growth and spread of certain types of cancer cells.
- Protecting against muscle wasting: Klotho has been shown to protect against muscle wasting in animal models, which may have implications for the treatment of conditions such as sarcopenia (age-related muscle loss).
- Regulating mineral metabolism: Klotho has been shown to play a role in regulating the metabolism of minerals such as calcium and phosphate, which are important for bone health and other biological processes.
It’s important to note that while these potential benefits of Klotho are promising, much of the research has been conducted in animal models or in vitro studies. Further research is needed to fully understand the potential benefits and risks of Klotho supplementation in humans.