Longevity (ISIRB and RBM3)

This probably led to God Helmet based feel good session :grinning: field

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I guess Astral Portal by SM would be awesome!!

Damn, that field is underrated.

This only is huge. And just one part of the field.

Anyone working on a brain stack or fixing some mental issues (adhd, autism, etc.) should strongly consider adding it at the beginning of his/her stack.

:100:

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I saw another post where someone was asking about fields for prions. I just wanted to make sure this thread popped up in the search window.

ā€œHere we show that synapse regeneration is impaired in mouse models of neurodegenerative disease, in association with the failure to induce RBM3. In both prion-infected and 5ƗFAD (Alzheimer-type) mice7, the capacity to regenerate synapses after cooling declined in parallel with the loss of induction of RBM3. Enhanced expression of RBM3 in the hippocampus prevented this deficit and restored the capacity for synapse reassembly after cooling.ā€

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ā€œA rose by any other name would smell as sweetā€. Still the title should be ISRIB & RBM3 (integrated stress response inhibitor).

This post shows this audio and Enhanced Brain Hemisphere Connectivity are working :laughing:

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Have been devoting a lot of time to languages and other fields but now wanted to use this as a sort of a rejogging or like riding a bike again with the world of mathematics.

Even with the fundamentals like algebra, I can feel this working right away, simple things today as Iā€™m trying to relearn everything from square 1, had begun solving SAT problems on Khan Academy and then had a subtle thought to use the FOIL method way back rom high school.

Little gems here and there but will capitalize on recreating those neural pathways that I had somedeal neglected over the years. But no worries that is what this field is for lol neural insurance.

Like reloading different saved checkpoints and levels in a video game I would imagine. :blue_heart: :heart_eyes:

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Love it!

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Has anyone felt less anxiety and less stress since listening to this?

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ya. it is a shock absorber. any kind of shock.

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[T]he molecule has restored memory formation in mice months after traumatic brain injuries and shown potential in treating neurodegenerative diseases, including Alzheimerā€™s, Parkinsonā€™s, and Lou Gehrigā€™s disease (also known as amyotrophic lateral sclerosis, or ALS). Oh, yeahā€”it also seems to reduce age-related cognitive decline and has imbued healthy animalsā€”mice, at leastā€”with almost photographic memory.

ā€œAlmost photographic memoryā€

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@El_Capitan_Nemo could this adversely affect cell apoptosis induced by Skin Scarring Repair?

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I agree this is the most powerful field of all the brain fields here, and Iā€™ve extensively tried almost all of them.

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Overtime you may start to remember everything, or atleast from my experience with a few fields like this.

Theyā€™ve done studies with fruit flies and CREB too like this.

Memories just resurface one by one.

Itā€™s breathtaking.

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Man I reaaaaally gotta stop overlooking fields. This field is amazing. Iā€™ve noticed a big noticeable leap in cognitive performance and mental clarity. I can finish my sentences without having to repeat what I just said because the person couldnā€™t fully understand me.

I feel way more functional than I have been in a long time. Iā€™m impressed and extremely thankful for this field. I added brain regeneration/plasma brain with this and its crazy good. Noticed my memory spiked up a lot too. This is going at the beginning of my brain stack for as long as itā€™s not replaced by another field.

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is this field good for the nervous system?

Listening to it again now and Iā€™m feeling a unique tingling in my left foot so I would assume it does.

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ChatGPT: ISIRB and RBM3 are both proteins that have been studied for their potential benefits in various biological processes. Hereā€™s a brief overview of each:

  1. ISIRB (Interleukin 1 receptor-like 1 binding protein): ISIRB is a protein that interacts with the interleukin 1 receptor-like 1 (IL1RL1) receptor and is involved in regulating the immune response. Studies suggest that ISIRB may play a role in the development and progression of various autoimmune diseases, such as rheumatoid arthritis and lupus. Additionally, ISIRB has been shown to have anti-inflammatory effects and may be a potential therapeutic target for inflammatory conditions.
  2. RBM3 (RNA-binding motif protein 3): RBM3 is a protein that binds to RNA and is involved in various cellular processes, such as RNA splicing and translation. Studies suggest that RBM3 may have neuroprotective effects and may play a role in promoting cell survival in conditions such as ischemic stroke and traumatic brain injury. Additionally, RBM3 has been shown to have anti-inflammatory effects and may be a potential therapeutic target for inflammatory conditions.

Overall, both ISIRB and RBM3 show promising potential benefits in various biological processes, including immune regulation, neuroprotection, and inflammation. Here are some of the proposed benefits:

ISIRB:

  1. Regulation of Immune Response: ISIRB plays a role in regulating the immune response and may be involved in the development and progression of various autoimmune diseases.
    2ā€¦ Rheumatoid Arthritis: A study published in the Journal of Autoimmunity found that ISIRB expression was reduced in the joints of rheumatoid arthritis patients, suggesting that it may play a role in the disease. Targeting ISIRB may be a useful approach for treating rheumatoid arthritis.
  2. Lupus: A study published in the journal PLOS ONE found that ISIRB expression was increased in the blood of patients with systemic lupus erythematosus (SLE), a chronic autoimmune disease. The study suggested that ISIRB may play a role in the pathogenesis of SLE and could be a potential therapeutic target.
  3. Anti-Inflammatory Effects: ISIRB has also been shown to have anti-inflammatory effects. A study published in the journal Arthritis Research & Therapy found that overexpression of ISIRB in mice reduced inflammation and protected against joint destruction in a model of rheumatoid arthritis.
  4. Rheumatoid Arthritis: A study published in the Journal of Autoimmunity found that ISIRB expression was reduced in the joints of rheumatoid arthritis patients, suggesting that it may play a role in the disease. Targeting ISIRB may be a useful approach for treating rheumatoid arthritis.

RBM3:

  1. Neuroprotection: RBM3 has been shown to have neuroprotective effects in several models of neurological disease and injury, including ischemic stroke, traumatic brain injury, and Alzheimerā€™s disease. Studies have suggested that RBM3 may promote cell survival and protect against neuronal damage.
  2. Anti-inflammatory Effects: RBM3 has also been shown to have anti-inflammatory effects in various models of inflammation. For example, a study published in the Journal of Neuroinflammation found that RBM3 reduced inflammation and improved outcomes in a mouse model of multiple sclerosis.
  3. Other Potential Benefits: RBM3 has also been implicated in other biological processes, such as regulating the cell cycle and promoting cell proliferation. Some studies have suggested that RBM3 may play a role in cancer progression and could be a potential therapeutic target for cancer treatment.

ISIRB and RBM3 both have potential benefits in various biological processes, although more research is needed to fully understand their effects.

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This may be another super useful antioxidant as an antidote for neurodegenerative disease. I

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never felt more well-being than after using this

Reminds me of childhood, honestly, I totally forgot what this sense of well-being felt like, full disclosure though Iā€™m running the Plasma audios as well. But this one makes me feel calm, absolutely calm and relaxed.

Here is a newer Research Article from last year, Small-Molecule Drug Reverses Neural Effects of Concussion | UC San Francisco

~ ā€œThis study reminds us that the brain is very plastic; it can be rewired and healed,ā€ said Rosi. ā€œBy briefly inhibiting this stress pathway, we may be able to restore healthy synaptic and cognitive function in many neurological conditions.ā€

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What is the difference between this one and GPDL1 for the brain? In laymanā€™s terms please? Just to understand how to use either. Thank youšŸ’—