Who knows how much things would have changed if they have succeeded.
Maybe they would have created a colonial empire too, or even expand their borders in the neighboring regions, although both would have been highly unlikely.
Any colonial ambitions would have been blocked thanks to the Ottoman expansion and domination of Eastern Mediterranean region(s), I mean, the Ottomans crushed the Mamluks, conquered North Africa, conquered the Balkans and beyond and expanded further south in the Arabian peninsula and even further west, Italy wouldn’t have been able to mess with the Sultan, nor with France, who was a Mighty Kingdom, nor with any other big power, But Italy would have had a Great time anyway, as they were EXTREMELY Rich (first banks of Europe) while separated, but united as one, nobody would have messed with them, that’s for sure.
I have in plan to study the Borgias too, and the Medici and Other Dinasties and powers, I want to know much more, since I only have an overall picture of the history of Europe, with very few in depth info.
Also, since i have mentioned the Ottomans, I need to post this in this thread too:
If the Ottomans haven’t blocked the Europeans to get cheap(er) goods, European powers would still have relied on their supply, and they wouldn’t have had to search for an alternative to the Silk Road(s)/Trade, which was owned by the Ottomans (in the Western areas of the renowned road), and Spain and Portugal wouldn’t have had to search for a new way to India/The East, and they wouldn’t have discovered the New World, nor colonize it.