This upgrade includes all of the previous fields in addition to the use of KROX20 and SCF (stem cell factor). In-depth studies using a mouse model show that cells with functioning KROX20 and SCF are present, they move up from the bulb, interact with pigment-producing melanocyte cells, and grow into pigmented hairs.
Without SCF, the hair in mouse models was gray and then turned white with age. Without KROX20-producing cells, no hair grew, the study said.
The new additions to this include restoration of the KROX20 (and SCF) proteins/cells induced ALA production for increased antioxidant effects (to counteract the hydrogen peroxide bleaching) etc.
2 - 3 times per day should be fine.