Beyond your personal enjoyment, no, it doesn’t matter.
It will be harder for you to interact with your NFT and could be easier for you to forget about your NFT with such a setup. Those would be “issues.” There can be an “out of sight; out of mind” issue. (See How to Better Connect with Servitors/Audios/Items/Mandalas for some helpful hints.)
Folding, however, is not a problem.
Maybe we’re meaning different things when you and I talk about “full scale,” but I haven’t heard anything about “full scale” as necessary. I have read where you don’t want to (excessively) trim your print–whatever scale you print yours at–because it’s the print which carries the field.
That should be fine, although folding is only a problem when it contributes to the “out of sight, out of mind” factor.