The HPGE project is a project of physical human enhancement through genetics. This project utilized over 80+ genetics to reach our goal of peak physicality of the human body concerning things like ( Muscle strength, growth, composition, flexibility, bone density, bone health, metabolism, hormones, joints, tendon strength and health, endurance, oxygen uptake, lung capacity, mobility, poison resistance, recovery, etc) These genes have been shown in many studies to be correlated with things like athleticism and human condition. The project is not only fit for athletes but everyday people who look to get the most out of life, especially if they have physical limitations holding them back. This project can turn your everyday person into a seemingly superhuman person with insane physical skills and impression.
(It should be noted that these are RNA changes which means that they are not permanent but they do last for a while and will last if you keep the mandala on you or listen to the audio everyday. Also overtime some mutations might actually become permanent through transcription)
Mandala + Audio
Project Summary
1: Actn3 - RR Genotype
Associated with muscle strength, power, reduced muscle damage, more fast twitch muscle fibers, and is highly related to athletic status.
2: PIEZO1 - E756del Genotype
Known as the “super tendon gene” this gene gives tendons more strength and allowed mice to jump 1.5 times further than mice without the gene. Mice with this gene were also able to reach higher top speeds.
3: ACE GENE - DD Genotype
This gene is related to many different athletic abilities, The I allele has been correlated to endurance while the D allele is associated with strength and power.
4: Sherpa - Epas1
A gene that helps your body use oxygen more efficiently, it was first discovered in the Tibetan people because of their lifestyle of living at very high altitudes.
5: Lack of NCoR1 gene
This gene is a conserved physiological modulator of muscle mass and oxidative function. The knockout of this gene in mice led to enhanced exercise endurance and strength, this is because the knockout of this gene increases muscle mass, mitochondria in muscle, increased oxygen uptake.
6: c18orf25 gene
This gene has been found to be related to muscle strength and power, it is triggered by exercise. Animals lacking this gene perform poorly during physical activity and have weaker muscles.
7: PPAR-a intron 7G>C
This gene has been found to be associated with increased endurance and aerobic performance. It increases maximal oxygen consumption.
8: PPARGC1A Gly482Ser gene
This gene has also been found to be correlated to endurance in elite level athletes.
9: EPOR gene mutation
An elite cross country skier named Eero Mantyranta had an extremely rare variant in this gene that mutated it and made his EPOR gene permanently turn on which gave him a naturally higher amount of red blood cells.
10: COL5A1 gene CC genotype
Known as the “flexibility gene” this gene provides flexibility and injury prevention to athletes and is directly associated with elite status in sports.
11: ACVR2B gene
Certain haplotypes of this gene are associated with higher muscle mass and strength.
12: CDKN1A gene C allele
The C allele of this gene has been associated with greater proportion of fast twitch muscle fibers and predisposition to power sports.
13: CNTF gene - GG genotype
This genotype of the gene has been associated with greater muscle growth and strength gains after workouts.
14: LRP5 v171 mutation
A rare gene that gives bones super strength through bone density. People with this gene can has bones up to 4x more dense than other humans.
15: AGTR2 A allele
The A allele of this gene has been found to be associated with faster 100m times and is also commonly found in power athletes.
16: ADRB2 - Gly16Arg polymorphism
This polymorphism is associated with better aerobic exercise performance, the Gly16 and Glu27 alleles of this gene have also been found to be related to power athletes.
17: IL6 mutation
The -174 G/C polymorphism of this gene has been found to be associated with elite power performance. The G allele of the IL6 -174 G/C polymorphism favors power athlete performance.
18: AMPD1 C allele
The AMPD1 C allele may help athletes attain elite status in sprint/power related sports.
19: ACTG1 gene
This gene is identified to have a positive association with strength athlete status.
20: IGF-1 genotype
The rare TT genotype of this gene has been associated with endurance and power sport performance.
21: IGF-2 genotype
The IFG2 rs680 GG polymorphism is highly prevalent in elite level sprinters, jumpers, and power athletes.
22: MORC4 gene G allele
The presence of the rs12688220 SNP and G allele is over-represented in Sprinters and power athletes and has also been found to increase proportion of fast twitch muscle fibers.
23: NOS3 G894T polymorphism
The G894T SNP rs1799983 has been associated with elite swimmer status.
24: DMD rs939787 T allele
The DMD rs939787 T allele was overrepresented in strength/power athletes indicating that it is favorable for strength/power performance.
25: TTN gene rs10497520 T allele
The rs10497520 T allele of this gene increased the chance of being an elite sprint/power athlete.
26: COTL1 rs7458 T allele
The COTL1 rs7458 T allele was in a group of SNPs that were correlated with power athlete status.
27: MPRIP rs6502557 A allele
The A allele of this gene was positively correlated to predisposition to strength and power sports, probably by influencing muscle contraction but it is not certain.
28: CACNG1 gene 196ser allele
The 196ser allele has been recognized as significant and associated with elite strength athletes status.
29: CALCR G allele of rs17734766
Endurance athletes and controls revealed that the CALCR G allele of rs17734766 was associated with power athlete status. This gene is related to bone density and probably increases bone strength which gives athletes an advantage.
30: MCTI A1470T - TT genotype
The MCT1 A1470T might be a polymorphism that influences athletic sprint power performance.
31: IGF1R C allele of rs1464430 A/C
The IGF1R C allele of the rs1464430 A/C polymorphism was more prevalent in elite power athletes.
32: CNTFR gene TT genotype
The TT genotype of this gene is frequently found in sprint/power athletes, non athletes with this genotype also had significantly higher leg extension power and vertical jump performance than other non athletes without the genotype.
33: DEC2 P38F4R
A gene mutation that allows people to function normally with just four to six hours of sleep a night. This is included for recovery especially with the world we live in today where a healthy sleep schedule is rare.
34: MSTN mutation (Limited expression)
Limited expression of the MSTN gene which produces myostatin, a protein that prevents muscle growth, will cause muscle growth to be highly accelerated.
35: 2X-MHC (Myh1 gene) overexpression in all muscles
Overexpression of this will cause more type 2x muscle fibers, these muscle fibers are the rarest in humans, they are also the biggest, strongest, and produce the most force but fatigue the quickest.
36: Dlk1 expression
Higher expression of this gene will lead to more muscle hypertrophy and recovery, it is a necessary protein in animals for muscle.
37: ACVR1B rs2854464
A large amount of athletes have shown that the ACVR1B rs2854464 A allele is associated with sprint/power performance.
38: IL1RN*2 gene
People with this genotype of the gene did better in competitive sports and responded better to high intensity exercise.
39: AGT Met235Thr
It has been found that the 235Thr allele of the AGT Met235Thr polymorphism might favor power sports performance and could be attributed to higher activity of angiotensin II that acts as a growth factor skeletal muscle.
40: FOCAD gene
Studies have shown that FOCAD rs17759424 C allele was associated with power athlete status.
41: HIF1A gene
The frequency of the HIF1A 582ser allele was significantly higher in weightlifters and increased their performance.
42: SOD2 gene
The SOD2 16Val allele was significantly higher in power athletes and is associated with significant increases of creatine levels.
43: mtDNA
There are multiple different alleles in this gene that help with athleticism but sprint/power athletes displayed a greater proportion of haplogroup F.
44: SUCLA2
The SUCLA2 rs10397 A allele has been recognized as a marker for strength athlete status but was also beneficial to other types of athletes.
45: UCP2 gene
This gene is expressed most in skeletal muscle tissues. The polymorphism C/T (rs660339) in the UCP2 gene resulting in Ala55val amino acids substitution has been associated with power athlete status, the C allele was over represented in italian power athletes.
46: CKM gene
The meta-analyses of publications on the CKM rs8111989 A/G allele or genotype differences between power and general controls found that power athletes had a significantly higher frequency of the G and GG genotype compared to controls.
47: CNDP1 and CNDP2
Studies revealed athletes had CNDP1 rs2887 or rs2346061 and CNDP2 rs3764509. These were all associated with power athlete status. The carriers of the rs2887 A allele, rs2346061 C allele, and rs3764509 G allele had increased odds of being a power athlete.
48: PPARGC1B gene
The rs10060424 C allele of PPARGC1B gene was designated as associated with power athlete status.
49: HSD17B14 gene
The rs7247313 G allele was annotated to the group of the markers associated with power athlete status.
50: TPK1 gene
TPK1 rs10275875 C allele has been found to be a genetic marker of power athlete status. It helps the body recover after exercise through B vitamins being involved in energy production and tissue repair.
51: GALNT13
Studies found that the GALNT13 G allele of rs10196189 A/G polymorphism was significantly overrepresented in elite sprinters.
52: MTHFR gene
In studies it was found that the MTHFR rs1801131 C allele was associated with power athlete status. It increases athleticism through factors leading to myogenic differentiation stimulation leading to increased muscle mass and induction of genes involved in metabolism.
53: RC3H1 gene
The RC3H1 rs767053 G allele has been described as a marker for power performance.
54: ZNF432 gene
In the GWAS performed in a large group of russian athletes the ZNF432 rs11865138 C allele was described as a marker of power athlete status.
55: MED4 gene
Studies revealed that the MED4 gene rs7337521 T allele is associated with elite strength athlete status.
56: WAPL gene
In a study done on Russian athletes it was revealed that the WAPL gene rs4934207 C allele was associated with elite strength athlete status.
57: CREM gene
Studies done on Jamaican, African American, and Japanese athletes revealed that the CREM A allele of rs1531550 G/A polymorphism was significantly overrepresented in elite sprinters.
58: IP6K3 gene
Studies found that the IP6K3 gene rs6942022 C allele was associated with power athlete status. It is likely through developing better coordination.
59: TRHR gene
The TRHR rs7832552 T allele has been shown to be correlated to increased lean mass in the body.
60: ARHGEF28 gene
It was found that the ARHGEF28 rs17664695 G allele was identified as being associated with elite strength athlete status.
61: GPC5 gene
In a genome study it was found that the GPC5 gene rs852918 T allele was identified as being associated with elite strength athlete status, probably through influencing the complicated processes of cell division and growth.
62: NRG1 gene
In a genome study it was found that the NRG1 rs17721043 A allele was associated with power athlete status.
63: CLSTN2 gene
In a study the CLSTN2 rs2194938 C allele was associated with power athlete status.
64: GABRR1 gene
In a GWAS study of Russian athletes it was found that the GABRR1 gene rs282114 A allele was associated with power athlete status.
65: Follistatin gene
Certain haplotypes of this gene are associated with increased muscle mass and strength.
66: MLN gene rs12055409 G allele
This polymorphism is associated with greater handgrip strength in elite level weightlifters.
67: ZNF608 gene
The rs4626333 G allele of this gene is associated with greater strength levels and fast twitch fibers in strength athletes.
68: GBF1 gene
The rs2273555 A allele of this gene is associated with greater fast twitch muscle fibers, handgrip strength, and greater competition results in weightlifters.
69: Weightlifting genome
Studies found 28 genes associated with elite weightlifters performance ABHD17C, ACTG1, ACTN3, ADCY3, ADPGK, AGT, ANGPT2, ARPP21, BCDIN3D, CKM, CNTFR, CRTFR, CRTAC1, DHODH, GALNTL6, GBE1, GBF1, HIF1A, IGF1, IL6, ITPR1, KIF1B, LRPPRC, MLN, MMS22L, MTHFR, NPIPB6, PHACTR1, PLEKGB1, PPARG, PPARGC1A, R3HDM1, RASGRF1, RMC1, SLC39A8, TFAP2D, ZKSCAN5, and ZNF608.
70: GH1 gene
Upregulation of this gene will increase amounts of HGH which helps with many bodily functions like bone and tissue growth.
71: BDNF rs1050109 A allele
The A allele of this gene is associated with greater fast twitch muscle fibers, handgrip strength, and sports performance.
72: AS3MT
This gene allows resistance to poisoning. It was developed in people who drank water with high amounts of arsenic who overtime developed a resistance to it and can now consume 80 times the normal fatal dose of arsenic.
73: DOCK3 gene:
The rs77031559 G allele of this gene is associated with higher testosterone in male athletes and bigger muscle fibers and more fast twitch muscle fibers.
74: ESR1 gene
The rs190930099 G allele of this gene is also associated with higher testosterone in male athletes.
75: GLIS3 gene
The rs34706136 TG allele of this gene is associated with greater testosterone levels and handgrip strength in male athletes.
76: GRAMD1B gene:
The rs850294 T allele of this gene is associated with higher testosterone levels and fat free mass in male athletes.
77: TRAIP gene
The rs62260729 C allele of this gene is associated with higher fat free mass, hand grip strength, and muscle fibers in male athletes.
2nd function:
Negate all negative or possible side effects of activating these genes and make these genes best suited towards the users and their goals.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724599/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023127/#!po=0.632911
https://www.mdpi.com/2075-4663/6/3/88
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032451/
https://pubmed.ncbi.nlm.nih.gov/29143592/
https://pubmed.ncbi.nlm.nih.gov/24485392/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023127/
Polygenic Profile of Elite Strength Athletes - PubMed (nih.gov)
https://www.researchgate.net/publication/347869972_Polygenic_Profile_of_Elite_Strength_Athletes
