Sapien Medicine - Album 4

Plasma Charged Mitochondria- What is the description?

Is it a steriod?

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Something that even you can’t remember!?
Is that even possible? :worried:

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Any suggestion when to use follistatin? Pre/post workout or doesnt matter?
There don’t seem to be a lot of studies about this, other than one in humans, but it just says they took it orally 1x a day - which suggests it does not matter when.

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No, it’s a protein.

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I’d say pre workout since it increases the muscle growth percentage…its like taking a boost…this way you can make more gains after workout. And then use the extreme muscle growth after workout…

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try doing this - listen to it 2x before and 1x after.

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I think the general consensus is to use hormonal audios after the workout, because you don’t build muscle while doing the exercises - you break muscle tissue - it’s only when they repair that the muscle rebuilds and gets stronger/bigger.

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Well… i wasnt checking lol.

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This Follistatin field is targetted only to muscles ? So then won’t it have it’s other whole bodily benefits like Sexual health, curing baldness, etc properties of it ?

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there are many different forms of follistatin, which play different roles in different parts of the body:

  • Follistatin 344 (FS-344): The most basic form of follistatin. It is primarily used in gene therapy, where the gene that helps create more follistatin is injected into the body using specially-designed viruses. Different parts of the body can then convert this ā€œgeneralā€ form of follistatin into more specific types in order to target different parts of the body [4, 5, 2, 6, 7].
  • Follistatin 315: The main form of follistatin found in the bloodstream. It primarily targets muscle tissue, which suggests it may be the best form of follistatin to supplement with [3, 7, 4].
  • Follistatin 288: A type of follistatin involved primarily in reproductive health. It also plays a role in tumor and cancer cell development [5, 4].
  • Follistatin 300: Another type of follistatin, involved in re-shaping nerve connections and in cardiac inflammation [8].

Follistatin Mechanisms

Follistatin blocks the action of many different proteins and hormones such as:

  • Activins, which are involved in apoptosis, metabolism, endocrine homeostasis, bone growth, fibrosis inflammation, neurogenesis, tubulogenesis of endothelial cells, and cancer development [9, 4].
  • Myostatin, which inhibits muscle growth [10].
  • GDF-11, a growth factor involved in bone development [11].
  • Follicle-stimulating hormone (FSH), involved in the development of eggs and sperm (gametes) [12].

Most of the follistatin’s effects on cancer and in reproductive health stem from its interactions with activins [4].

In contrast, follistatin’s effects on muscle growth are related to interactions with myostatin [13].

Health Benefits of Follistatin

Insufficient Evidence for:

1) Muscle Growth

Follistatin has gained attention in the bodybuilding community due to claims that it can significantly boost muscle mass, although there are relatively few scientific studies that directly back this up in healthy human subjects.

A study found that supplementation with egg yolk-derived follistatin (MYO-X) led to increased muscle mass in 37 college males when taken at 10 to 30 grams per day together with resistance training for 8 weeks [14].

One way that follistatin may accelerate muscle growth is by inhibiting myostatin, a protein that limits muscle development [15, 16, 17].

For example, a monkey study found that increasing the production of follistatin led to a corresponding decrease in myostatin activity and a significant increase in muscle growth [18].

In mice, follistatin stimulated the development of muscle cells, leading to enhanced muscle growth and repair [6, 10].

However, follistatin increased muscle growth even in mice that were genetically modified to lack myostatin, showing that follistatin affects muscle growth in other ways that are not directly related to myostatin [16, 19].

Although this is the most common use of follistatin, the evidence to support it is insufficient. More clinical trials on larger populations are needed to confirm these preliminary findings.

2) Preventing Muscle Loss

In a study of 6 male patients with Becker muscular dystrophy (a muscular disorder that specifically affects the legs and pelvis), follistatin injections increased muscle strength, leading to improvements in the patients’ symptoms without any adverse side effects [5].

Boosting follistatin levels has also been tested as a treatment for sarcopenia, an age-related muscle-wasting disease. In old mice, daily injections of epicatechin (a natural compound that increases follistatin levels) led to increased overall muscle strength. The same treatment in 6 human subjects increased their hand grip strength after seven days [20].

Follistatin also increased life expectancy in mice with spinal muscular atrophy, a genetic disease that involves muscle wasting. This suggests that follistatin could be used as a therapy technique due to its positive effects on muscle maintenance and growth [21].

Taken together, the evidence is insufficient to claim that follistatin helps prevent muscle loss until further clinical research is conducted.

3) Baldness

A small trial on 26 men with male-pattern baldness found that a single injection of follistatin with other growth factors increased the number of hairs on the head as well as their thickness (follicle density and hair shaft thickness). These beneficial effects lasted for up to a year with only a single treatment without needing repeated administrations [22].

A single clinical trial, despite its promising results, cannot be considered sufficient evidence that follistatin helps with male-pattern baldness. Larger, more robust clinical trials are needed.

Help Protect Yourself From Illness and Viruses by Optimizing Your Health!

Boost your immune system by optimizing your entire body with a gene-based approach to your health. Download our guide to find out how you can take your health into your own hands and create a regimen that is designed to keep your body as healthy as possible.

Help Protect Yourself From Illness and Viruses by Optimizing Your Health!

Boost your immune system by optimizing your entire body with a gene-based approach to your health. Download our guide to find out how you can take your health into your own hands and create a regimen that is designed to keep your body as healthy as possible.

4) Role in Reproductive Health

A number of findings indicate that follistatin seems to have some role in reproductive health, although its precise role is not yet entirely clear [23, 24].

In men, seminal fluid is rich in follistatin, although the levels of follistatin don’t seem to be directly related to sperm count [25, 26].

For women, follistatin promotes folliculogenesis, the process that prepares eggs to be released from the ovaries during ovulation [27, 24].

Follistatin levels are reduced during menopause but can be elevated using hormone replacement therapy [28].

A study of 7 women found that increased follistatin levels during the third trimester of pregnancy were associated with healthy labor and child delivery [29].

Follistatin also inhibits the activity of activins, which play a role in many aspects of reproductive health.

For example, activins are involved in the development of reproductive organs (testes and ovaries), and problems in normal activin function are related to tumors in those organs [30].

An increase in activin levels in women is correlated with reproductive aging [30].

Abnormalities in follistatin and activin activity have also been linked to polycystic ovary syndrome and problems during pregnancy [30].

Further clinical research is required to clearly establish the role of follistatin in reproductive health and determine if it can be therapeutically used for reproductive issues.

Animal and Cell Research (Lack of Evidence):

Scientists are also investigating the potential effects of follistatin on other health conditions. Because the research is still at the animal and cell stage, there is no evidence that follistatin will have the same effects in humans.

Preventing Fat Gain

Boosting follistatin levels in mice led to reduced fat gain and also decreased the size of the fat-storing cells (adipocytes) [31].

A series of related mice studies suggest that these effects may also be due to follistatin’s ability to inhibit myostatin [32, 19, 33].

By reducing myostatin levels, follistatin may have the potential to fight obesity as well as prevent diabetes as seen in mice studies [31, 32].

Arthritis

Follistatin significantly reduced joint inflammation and cartilage degeneration in mice with arthritis. This suggests that follistatin has potential as an anti-inflammatory drug for treating arthritis, but clinical research is needed [34].

Cancer Development.

Preliminary research suggests that follistatin may play a role in either inhibiting or promoting cancer growth, depending on the type of cancer. Because most of this research is still at the animal and cell stage, there is no evidence that follistatin will have the same effects in humans. Do not under any circumstances attempt to replace conventional cancer therapies with follistatin.

So far, follistatin has been found to play a beneficial role in many different types of cancer, including:

  • breast cancer
  • lung cancer (non-small cell lung cancer)
  • liver cancer
  • ovarian cancer

However, follistatin may play a negative role in other types of cancers, such as:

  • esophagus cancer
  • stomach cancer
  • skin cancer (melanoma, basal cell carcinoma)
  • prostate cancer

Follistatin’s Beneficial Effects on Cancer

A study analyzing tissue samples of human breast cancer patients found higher follistatin levels in those of survivors. This suggests that follistatin may play a protective role in this type of cancer [35].

In several cell studies, follistatin was found to reduce the survival rate of breast cancer cells, while also preventing the spread of cancerous cells in the body (metastasis) [35, 36].

In a study of mice with breast cancer, follistatin had no impact on tumor growth but did prevent the cancer cells from spreading to the rest of the body [37].

Cell studies of non-small cell lung cancer and ovarian cancer showed that follistatin and follistatin-like proteins prevented the growth and spread of cancer cells [38, 39, 40].

In living mice with lung and ovarian cancers, follistatin reduced tumor growth and prevented cancer cells from spreading, which allowed the mice to survive longer [41, 42].

In liver cancer, follistatin increased the growth and recovery of the liver after tumor-removing surgery in rats [43, 44].

However, it has also been found that liver tumors in rats and mice tend to have increased follistatin levels, making follistatin’s role in liver cancer a bit unclear [45].

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Plasma Charged Mitochondria… what a jewel is this one :relieved:

Can it become addictive though? Lol

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It’s a gem :gem: we’re so lucky round here, healing from the inside out :blush:

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Thanx for posting this @Blissing_soul

@_OM is going to love you

He gets off on these research papers ;D

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YES!!! True Elixir…

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Would you say Plasma Mitochondria supersedes Brain Regeneration? Or two completely different applications of the brain fields?

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Well all I can say for now is that mithocondria are found in almost any cell of the body, not only in the brain

So I’m not sure if you can say it can replace the other one, it’s a more generalized application

Indeed I feel it all over my body and feel so damn good to me

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That’s true it’s in all cells. Hmm… I used it 2x and felt more in my head area so thought that. Thanks!

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Brain is very rich in mithocondria

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