The text you provided is referring to the role of a protein called PCSK9 (proprotein convertase subtilisin/kexin type 9) in the body and the effects of its downregulation.
PCSK9 is a protein that is predominantly produced in the liver 1. It plays a crucial role in regulating the amount of cholesterol in the bloodstream 2. Specifically, PCSK9 binds to the LDL receptor (LDL-R) on the surface of cells, leading to the degradation of the LDL-R] 3. This results in higher plasma LDL-C (low-density lipoprotein cholesterol) levels, also known as “bad” cholesterol 4.
LDL cholesterol is often referred to as “bad” cholesterol because it can build up on the walls of your arteries and form plaque, which can lead to heart disease and stroke 5 10. On the other hand, HDL (high-density lipoprotein), or “good” cholesterol, absorbs cholesterol in the blood and carries it back to the liver, which then flushes it from the body 6. High levels of HDL cholesterol can lower your risk for heart disease and stroke 7.
When PCSK9 is downregulated or removed from your body, it means that less PCSK9 is available to bind to LDL-R. This results in a higher fraction of LDL-R recycling towards the cell surface. As a direct consequence, the cells have the capacity to remove more LDL-C from the circulation, resulting in lower LDL-C plasma levels 8. This is generally considered beneficial because it can reduce the risk of developing atherosclerosis (hardening and narrowing of the arteries) and cardiovascular diseases 9 10.
However, it’s important to note that while lowering LDL levels and increasing HDL levels is generally beneficial, the specific impact on an individual’s health can vary depending on their overall health status and other risk factors. Therefore, any changes to one’s cholesterol levels should be done under the guidance of a healthcare professional.
In summary, the downregulation of PCSK9 leading to a decrease in LDL levels and an increase in the ratio of HDL is generally considered a positive effect in terms of cardiovascular health. However, individual health circumstances can influence this outcome. It’s always best to consult with a healthcare provider for personalized advice.