Agreed, but we are speaking about people with already expressed morphology. In my case skew towards lower body is absolutely far greater than abdominal and greater than most females, nothing like infamous lipedema, which is specific to women (and I’m male). This is genetically and epigenetically driven of course, but as the cells are already developed and worse are in rather non-labile state, changes to genes can only go so far as affecting them in say 10 years.
And also my point is that I was extremely overweight in early years, losing lots of weight and doing any kind of fitness exercise only in adulthood. The difference is that it’s living tissue now, not only genes
To change the existing body fat stores something different from eating patterns should be changed, possible with just restriction of course as the old cells gradually rotate not to full replacement hopefully, but this is very slow and unreliable.
Especially if visceral fat is long time ago dealt with and rest is ton of subcutaneous cellulite-like fat which actually has little negative health impact on objective markers, but is harder to be reached as well by a bodily conventional metabolism.
Stages that women develop are sometimes literal lipomas in how they exist and after being developed such stores can only be extracted, sometimes not needing any solvent even, as fat mass isn’t with much blood supply or innervation, yet easily proceeds to exist, such as the extent of the disease. And lipedema has high level of prevalence in women. Gene therapy isn’t going to affect already developed disorder of that kind.
Sorry, not arguing with your point, just saying that true advanced approach should be wholistic in this department as well.