One thing that hasn’t been mentioned and may be of interest:
This field will encourage drainage of waste buildup in the brain’s glymphatic system.
Glutathione Super Anti-Oxidant and Lymphatic System Blockage Removal and Enhanced Drainage would complement these effects from the field, and aid in waste product clearance.
(The Longevity Series fields, Anti Aging field and brain-related fields would also complement this field more generally.)
Here is an excerpt from a mini-review article of the glymphatic system.
Abstract
The glymphatic system is a glial-dependent waste clearance pathway in the brain, in place of lymphatic vessels, dedicated to drain away soluble waste proteins and metabolic products. Specifically, the glymphatic network serves as a “front end” for waste clearance, and is connected downstream to an authentic lymphatic network, associated with dura covering the brain as well as cranial nerves and large vessels at the skull exits. The anatomical and functional interconnections between these two networks are not completely understood. Several key physiological processes have been identified that control glymphatic transport function and waste clearance from brain.
In this review, we aim to provide an overview and discussion of the concept behind the glymphatic system, current evidence, and controversies, while specifically focusing on the consequences of aging and evidence of its existence in human brain. Discovering novel strategies for optimizing and maintaining efficient brain waste clearance across the lifespan may in the future prove to be important for preventing cognitive decline and sustaining healthy aging.
Introduction
Waste removal from the central nervous system is essential for maintaining brain homeostasis across the lifespan. Two interconnected, dynamic networks were recently uncovered, which may provide new information concerning the conundrum of how the brain manages waste removal in the absence of authentic lymphatic vessels (LVs). The glymphatic system serves as the brain’s “front end” waste drainage pathway that includes a perivascular network for cerebrospinal fluid (CSF) transport [1, 2], which is connected to a downstream authentic lymphatic network associated with the meninges (dura), cranial nerves, and large vessels exiting the skull [3-5]. The anatomical and functional components of the two systems are complex, and the processes by which they physically interconnect are only partly understood.
The first pioneering studies documented that soluble amyloid beta (Aβ) protein and tau oligomers – metabolic waste products whose buildup is associated with Alzheimer’s disease (AD) – were transported from the interstitial fluid (ISF) space and out of the brain via the glymphatic system [1, 6]. This information was followed by another hallmark study reporting that slow wave sleep enhanced glymphatic Aβ clearance from brain when compared to wakefulness [7]. Collectively, this information was met with excitement in the neuroscience and clinical communities because maintaining efficient brain waste drainage across the lifespan – possibly by preserving normal sleep architecture – emerged as a novel therapeutic target for preventing cognitive dysfunction and decline. The idea of maximizing brain “waste drainage” as a new preventive or therapeutic target for neurodegenerative disease states was further strengthened by animal studies providing evidence of declining glymphatic transport efficiency in healthy aging [8], AD models [9], traumatic brain injury [6], cerebral hemorrhage [10], and stroke [11].
Also, @TCS I believe you requested a field for the glymphatic system. 