Transforming Growth Factor Beta, TGF-β field
Transforming Growth Factor Beta (TGF-β) is a multifunctional cytokine. In the human body, many types of cells have the ability to produce and secrete this cytokine. TGF-β is involved in the mechanism of many diseases, playing a dual role of inhibiting or promoting diseases, including wound healing, tissue fibrosis, atherosclerosis, cancer occurrence and metastasis, autoimmune diseases, diabetic complications, and Alzheimer’s disease Neurological damage caused by Haimer’s disease is closely related to TGF-β.
There are three isomers of TGF-β, among which “TGF-β2” is a hot research topic in recent years, and its key role in regulating immunity is as follows:
Reduce inflammation: through regulatory T cells, help the immune system balance and reduce inflammatory substances.
Reduce allergic reactions: reduce the allergic index caused by IgE (immunoglobulin E), reduce the body’s oversensitivity.
Improve food tolerance: Help the human body build tolerance and slow down the chance of human allergies caused by foreign proteins in food.
Resist virus and bacterial invasion: promote the secretion of IgA (immunoglobulin A), help the development of intestinal mucosa, and resist the invasion of foreign substances.
Avoid infection with influenza A virus H1N1, reduce the severity and shorten the course of the disease.
The content of human TGF-β2 is highly related to the balance of immune system
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Common genetic allergic diseases, such as: atopic dermatitis, asthma, allergic rhinitis, etc., all lack TGF-β2 immune regulatory factor in the body.
According to international journals, long-term supplementation of TGF-β2 can increase the concentration in the body, improve physical fitness, reduce inflammation, slow down the allergic index, repair tissue, prolong the protection of breast milk for infants and young children, improve the body’s tolerance to food, and maintain the function of the digestive tract , is an important source of immune system health for infants and adults. In addition, TGF-β2 is involved in the mechanism of other diseases, including anti-renal fibrosis, promoting wound healing, improving psoriasis, xerosis, lupus erythematosus, systemic sclerosis, multiple sclerosis, rheumatoid arthritis autoimmune diseases [1