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Berserker’s Wrath (TP-301) orchestrates a powerful, activity-dependent signaling journey from the synapse to the nucleus, where the sum of its effects exceeds the individual components. It begins by enhancing the structural foundation of your neural networks through the overexpression of SHANK3 and PSD95. These proteins stabilize and organize synapses, optimizing communication and indirectly boosting cognitive functions like memory and learning.
Next, Homer-1 refines synaptic signaling, setting the stage for the activation of PKC (Protein Kinase C) by PMA (Phorbol 12-myristate 13-acetate). This triggers a cascade that activates RAS, a critical link between surface signals and nuclear responses. The inhibition of GSK-3 by CHIR99021 keeps RAS fully engaged, ensuring efficient signal transmission through GRB2, SOS1, RAF, and MEK, driving the signal towards the nucleus.
In the nucleus, CREB (cAMP response element-binding protein) is activated, initiating the transcription of genes crucial for neural plasticity and survival. Finally, the upregulation of FOS (cFos) and JUN (cJun) forms the AP-1 dimeric complex, which drives the expression of genes that support cellular growth and long-term synaptic strengthening.
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