I’m sorry if this post is off-topic.
The Down Syndrome audio blocks the production of PKR (Protein kinase R) in hippocampal cells. PKR activates the ISR (Integrated stress reponse) which decreases protein production in the hippocampus.
The hippocampus is involved in learning and long-term memory formation. It is also involved in prediction and imagination.
A few studies on healthy mice show that inhibiton of PKR resulted in enhanced long-term memory and synaptic plasticity. For more information, please read this article.
Therefore, because mouse study results do not always mean the same results in humans, the Down Syndrome audio might improve cognitive functions.