could we make a fat to ojas field?
I mean… if it’s possible to convert them into stem cells, perhaps we could do something along those lines?
please make automated pudendal nerve floss to treat pudendal nerve entrapment and pudendal neuralgia
video reference for pudendal nerve floss is below
Hello Captain, I just realize that NFT submission is stopped, so i decide to post my researches about gene therapy on eyesights here. Maybe some info could be useful for your future projects.
Objective: Improve and Recover Poor Eyesights
Suggested Method for this NFT : Gene Therapy for Myopia (nearsighted)
Gene Therapy
Gene Therapy is getting popular from last decade. Some people are born with bad eyesight because they inherited from their parents’ mutated eye genes. Non invasive eye treatments (like eye exercises, Bates methods….) may offer little help because their eyes are programmed to be deteriorated. With invasive methods (laser surgery, eyeglasses), their eyes further affirm to go downhill as the method does not cure the root cause.
Genes, which are made of DNA, are the cell’s instruction manual, providing information on what molecules the cell should make and how the cell should act. The purpose of gene therapy is to try and change how the cell is acting by putting in a new gene or replacing a broken gene.
Common types of gene therapy:
- Gene Replacement (a new gene is introduced into a cell to replace a broken gene)
- Gene Editing (molecular scissors are used to “edit” a broken gene by cutting out the mutation)
- Gene therapy that stops cell death (stop retina cell from dying, so vision will not be lost)
- Gene Therapy to replace antii-vegf injections (Anti-VEGF injections are the most common treatment for Age Related Macular Degeneration and Diabetic Macular Edema, due to blood vessels in the retina grow uncontrolly and leak fluid into the eye. It slows down the growth of blood vessels)
Gene Therapy & Clinical Trials to Treat Vision Loss | Fighting Blindness Canada - Gene therapy given through eyedrop – Case study: A patient has mutations in a gene that helps produce a protein called collagen 7, which holds together both skin and corneas. The treatment, called Vyjuvek, uses an inactivated herpes simplex virus to deliver working copies of that gene. The eyedrops use the same liquid as the skin version, just without the added gel.
Gene therapy eyedrops restored a boy's sight. Similar treatments could help millions | AP News
Eye Genes
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RPE65 gene is injected into the eye, under the retina because it is packaged into a safe virus called adeno-associated virus (AAV). The genetically modified AAV was able to significantly restore vision in blind children, enabling them to complete tasks such as walking through a maze without bumping into soft objects, or catching a ball. This gene also helps to correct Age related macular degeneration (AMD)
Gene Therapy for Macular Degeneration & Other Eye Diseases | BrightFocus Foundation -
SERPINE3 gene is highly expressed in zebrafish eye. A functional experiment is tested on zebrafish because its retina is organized into layers which are similar to those found in humans. The lab deleted Serpine3 during zebrafish development, causing adult animals to have deformed eyes and disrupted the organization of the cell layers in the retina. This suggests that vertebrate eyes need the product of serpine3 in order to function properly. The lab also found that Serpine3 are associated with refractive errors in the eye and macular degeneration, suggesting that this gene may also play a role in human eye diseases and good vision.
Evolution: Poor eyesight reveals a new vision gene | eLife -
LEPREL1 gene encodes an enzyme that is essential for the final modification of collagen in the eye. In the absence of the active form of this enzyme, aberrant collagen is formed, causing the human eyeball to be longer than normal. As a consequence, light beams entering the eyeball focus in front of the retina rather than on the retina itself and myopia emerges.
Researchers identify gene that leads to myopia (nearsightedness) | ScienceDaily -
PDGFRA gene on chromosome 4q12 is significantly associated with corneal astigmatism. PDGFRA is a receptor for platelet-derived growth factor, which is expressed in many retinal tissues in the eyes and appears to contribute to ocular development.
Genome-Wide Meta-Analysis of Five Asian Cohorts Identifies PDGFRA as a Susceptibility Locus for Corneal Astigmatism -
Genes causing myopia
• Single nucleotide polymorphism (SNP) in these genes results in high myopia
BLID, SCO2, 62CTNND2, 63 MIPEP, 65ZC3H11B, VIPR2 66, 67 and SNTB167, 68
• Molecular cause of myopia is attained by modification in the genes
ANTXR2, KCNQ5, LAMA2, PRSS56, RASGRF, RDH5, VAX2, SHISA6, TJP2, TOX/CA8, ZIC2 68, 70
• Sporadic Myopia can be caused by mutation of these genes
CTSH, LEPREL1, SCO2, SLC39A5, ZNF644, 56 and WNT7B
• Age-related macular degeneration(AMD) can be caused by mutation of these genes
CFH72, ARMS2-HTRA1
• APLP2 gene can cause myopia in teenagers if they read for more than an hour
• LEPERL1 gene secretes an enzyme that participates in the last stage of collagen formation in the eye. When the enzyme is not active, an abnormal collagen is formed which makes the eyeball bigger than normal. Thus the light gets concentrated in front of the retina.
Genetics of Eyesight
- Some Eye gene functions:
• Genes undergoing ion transport, regulation of membrane potential, and channel activity are KCQN5, CD55, CACNA1D, KCNJ2, CHRNG, and MYOID.
• Neural signaling is by
GRIA4, GJD2, RASGRF1, 70DLG2, KCNMA1, LRRC4C, RBFOX1, TJP2.
• Extracellular matrix remodeling is by
LAMA2, BMP2,3, and ANTXR2.
• Retinoic acid metabolism by these genes involves in the development of the eyes.
RDH5, RURB, CYP26A1.SIX6, PRSS56, CHD7, ZBTB38, ZIC2, 70BMP4, DLX1
• Genes that participate in retinal ganglion cell projection are ZIC2 and ZMAT4.
• The SCO2 gene is responsible for the metabolism of copper, which is essential for the regulation of oxygen in the eyes.
Extra Info, and not intended for this NFT
7. Hyperopia (Farsightedness)
• PDE11A plays an important role in conduction of signals for the management of eye growth. Tetratricopeptide repeat domain 30A (TTC3OA) protein and the alkylglycerone phosphate synthase (AGPS) are also involved in signal conduction between neurons along with PDE11A. The variant PDE11A is responsible for causing hyperopia.
• Cataracts develop by the mutation of AGPS, which is combined with a disorder of the multisystem development.
The MFRP gene helps to maintain the shape of the cornea and aids in the focusing mechanism. Mutation of this gene leads to farsightedness, retinitis pigmentosa, and micropthalamos.
8. Astigmatism (An uneven cornea surface which causes near and far vision blurry)
• The PDGFRA gene binds to the receptor called platelet-derived growth factor (PDGF). PDGF is identified in the multiplying of retinal tissues, corneal epithelium, and it regulates the movement of corneal fibroblast. When the PDGFRA gene is arranged with three SNPs on chromosome 4q12, it results in the corneal bio-metrics leading to assurance of corneal astigmatism.
• The SHH (sonic hedgehog) gene plays a vital role in the development of several tissues, which also includes the eye. Studies have proclaimed that SHH gene is associated with irregular astigmatism.
• The VAX2 gene plays a major function in cornea development and increases the risk of astigmatism.
- Presbyopia (Cannot see close objects due to aging)
• Crystalline alpha A (CRYAA) comprises two genes: alpha-A and alpha-B. Mutations in these genes lead to congenital cataract and presbyopia.
• The protein concealed by a gene called RP1L1 along with retinal-specific protein plays a crucial role in altering the rod photoreceptors, thereby affecting the photosensitivity. Occult macular dystrophy is caused by the variation of this gene.
Traditional non-invasive methods:
- Eye Exercises
- Bates Method (swinging body left and right while eyes are relax and not focusing at anything)
- Staring at Autostereogram (3d pictures that forces both eyes to work together HARD)
- Increase bloodflow to head or lower dantain (more oxygen for better vision, temporary fix)
- Gabor Patch (train the communication between optic nerve and brain on object recognition, rather than fixing the eyeball structure)
Traditional Invasive methods: - Laser Surgery (Reshaping cornea)
- Eyeglasses (Changes and locks your eyeballs at the current shape, which prevents them to return to the 20/20 round shape)
- Contact Lens (Soft, Hard, early age corrective len) (Dry up the eyes, block eye from inhaling oxygen)
- Pressure Corrector (Only available in Russia. Doctors use pressure to reshape eyeballs so that light can focus at Macula proeprly – the small area of retina which registers sharp, central vision)
Invasive methods can solve patients’ eyesight issues quickly, but it only treats the symptoms, not the causes. Hence, eyesights usually continue to get worse along with time. Non invasive methods usually require more times, and the results are mixed, depending on the patients’ health, diet and living style.
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– A new research finding that came out after the release of Kidney and Bladder Specialist so it’s worth taking a look at for a future kidney related update/release.
Duke-NUS and NHCS scientists first in the world to regenerate diseased kidney
Blocking an immune-regulating protein reverses the damage caused by acute and chronic kidney disease, a preclinical study suggests.
They teamed up with scientists in Germany to investigate the role of IL-11, which is known to trigger scarring in other organs, including the liver, lungs and heart, in acute and chronic kidney disease.
Their findings implicate the protein in triggering a cascade of molecular processes in response to kidney injury that leads to inflammation, fibrosis (scarring) and loss of function. They also discovered that inhibiting IL-11 with a neutralising antibody can prevent and even reverse kidney damage in this setting.
“We found that IL-11 is detrimental to kidney function and triggers the development of chronic kidney disease,” said Professor Cook. “We also showed that anti-IL11 therapy can treat kidney failure, reverse established chronic kidney disease, and restore kidney function by promoting regeneration in mice, while being safe for long term use.”
More specifically, the researchers showed that renal tubular cells, which line the tiny tubes inside kidneys, release IL-11 in response to kidney damage. This turns on a signalling cascade that ultimately leads to increased expression of a gene, called Snail Family Transcriptional Repressor 1 (SNAI1), which arrests cellular growth and promotes kidney dysfunction.
In a preclinical model of human diabetic kidney disease, turning off this process by administering an antibody that binds to IL-11 led to proliferation of the kidney tubule cells and reversal of fibrosis and inflammation, resulting in the regeneration of the injured kidney and the restoration of renal function.
While clinical trials of an antibody that binds to another pro-fibrotic molecule called transforming growth factor beta have been unsuccessful, this new approach brings hope of a new target.
“By boosting the kidney’s intrinsic capability to regenerate, Prof Cook and Asst Prof Widjaja have shown that we can restore function to a damaged kidney,” said Prof Coffman, who is also the principal investigator of the Diabetes Study in Nephropathy and other Microvascular Complications (DYNAMO), a large collaborative study that aims to find new solutions for the prevention and treatment of diabetic kidney disease. “This discovery could be a real game-changer in the treatment of chronic kidney disease—which is a major public health concern in Singapore and globally—bringing us one step closer to delivering the benefits promised by regenerative medicine.”
https://www.duke-nus.edu.sg/allnews/duke-nus-nhcs-regenerate-diseased-kidney
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please make a field about upper eyelids, regarding some genetic features (not due aging),
to remove excess skin and fat from eyelids, around eyes,
remove puffy, hooded and droopy upper eyelids,
and make uplifted, prominenet and big upper eyelids ,
and a field to make eyes prominent not sunken
for women
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A semaglutide field that works like wegovy but hast a permanent and safe effect.
1 Like
A yin yoga field. Similar to Tibetan rites but the focus would be on the deep relaxation, flexibility and stretching of the muscles.
please make an automated pelvic floor relaxation field that consist of automated reverse kegel and a series of yoga pose that relaxes the pelvic floor
Request:
Diabetes Specialist field (similar to those on the 22 dollar tier fields for heart, etc) that consists of various fields that reverse both Type 1 and Type 2 permanently along with other potential field sets that reverse/fix complications of the issue as well
or atleast further prevents complications (anyway that dream thinks is better if this is a potential field)
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This would be a game-changer, I second this
3 Likes
can you please add attract luck weath old tone version, that you removed before?
Request:
A field that targets the love handles/obliques and melts the fat around them and maybe tightens the skin.
Thank you.
2 Likes
please do a smart field on pudendal nerve decompression via laparoscopic surgery which attempt to remove muscle or tissue that is compressing the pudendal nerve. I have suffered the this pudendal nerve symptom for more than 8 years, most doctor and chiropractor doesn’t have any idea how to deal with this and i am at my wits end, please help.
Maya Civilization Field
Simulate fields like Atlantis and enter Mayan life and energy
A new weightloss combination field with glucose & fat metabolism & leptin & diabetes please 
A field for feeling safe and comfortable in our own skin something like hope & happiness just for the other emotions 
🫂:smiling_face_with_three_hearts:
Updated Mindfulness field :)
I would like to see the alchemical revision of trauma back on youtube
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