As there is a huge demand for an all exclusive hair NFT and Tiger Mane fizzled out, a public project with enough number of copies for all members and future members, to be released on sapienshop or gumroad (like Vision of Clarity) with both mandala and audio, if Captain decides to do.
Inputs will be taken from Another Hair Project, requests thread and also add anything here that would help the project.
Interested people, please vote again to get some idea on the count.
- I will buy this
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Draft script
Objectives of Blueprint of Hair
To provide the user with a perfect blueprint of hair with renewing and regenarating scalp in order to fix all the hair problems:
- Alopecia Areata (autoimmune disease that impacts hair follicles)
- Androgenic alopecia (male-pattern baldness and female-pattern baldness)
- Telogen effluvium (temporary hair loss due to a stressor)
- Receding hairline
- Gradual thinning of hair on the top of head (crown)
- Patchy bald spots
Physical - Damage Control
Damage control
- Endocrine flush - removing excess estrogen from body which causes thyroid and endocrine system problems and maintain healthy levels of hormones
- Smart degradation of androgenic receptors in the scalp (Sources - 1,2,3)
- Remove excess DHT from scalp or the negative effect of DHT on the hair follicles without causing imbalance in the body (Dutasteride Scalp field) (Source - 1)
- Ketoconazole is a topical antifungal that can disrupt DHT pathways in the scalp. (Source - 1)
- Saw palmetto: An herbal mix with saw palmetto berries can reduce levels of DHT by 32%. (Source - 1)
- Detoxify kidney & adrenal glands
- Automated blood purifier - Detoxify the body from acidosis (lower pH level of blood) and make into alkaline especially the scalp
- Automated lymphatic effusion - Drain the excess fluids and toxins from the hair follicale stem cells on the scalp
Stress
- Any medical condition that puts a stress on the body and the hair cycle
- Removing excess cortisol and corticosterone from the body
- Remove the autoimmune disease markers from the body - class of Janus kinase (JAK) inhibitors
Protection from Radiation
- Protection from all forms of radiation and EMF frequencies (Source - 1)
Hair Rejuvenation & Growth - Research
Research
Epigenetics
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One major way stem cells turn into hair follicle cells is through DNA methylation by an enzyme known as DNMT1. DNMT1 is required to keep the hair follicle in the growth phase by turning off genes through methylation [Source - 1]
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Stem cells have special proteins called polycomb groups (PcGs), which determine the specific cell type a stem cell will become, like a hair follicle cell. A protein called Jarid2 is necessary for one of the PcGs to function. If we can find things in our environment that increase our DNMT1 enzyme or increase Jarid2 in our hair cells, then we may be able to find a way to keep our hair growing. [Source - 1]
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Catagen (Regressing via nRNAs) is the shrinking of the hair follicle after the initial growth phase. The progression from growing to regressing includes a significant increase in a specific nRNA named miRNA-22. Noncoding RNAs are not all bad. Dicer, an enzyme that makes nRNAs, was found to be essential for normal hair follicle development and growth. Dicer creates specific nRNAs that are important for maintaining anagen. When Dicer is no longer present, the hair follicle regresses. We need to find things that either decrease miRNA-22 or increase Dicer. [Source - 1]
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Telogen, like catagen, pushes the hair closer to its shedding phase. It is no longer growing, just resting, waiting for its day to fall out in the exogen phase. We could prevent telogen by finding ways to decrease the unique PcG proteins that turn off anagen. If our hair has already made it to telogen, we may be able to keep it there and stop it from shedding, creating fuller looking hair. To do this we need to find factors that could keep low levels of or simply decrease beta-catenin to avoid moving into exogen and shedding our hair. [Source - 1]
- Removal of the suppression of the GAS6 gene expression and increase its supply (inhibited by corticosterone produced in adrenal cortex) (Source - 1, 2, 3)
Adipose Tissue & Stem Cells
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Human adipose tissue (AT) is a rich and easily harvestable source of stem cells and various growth factors (GFs). Increasing evidence shows that dermal adipocytes are intricately associated with hair follicles (HFs) and may be necessary to drive follicular stem cell activation. HFs are closely associated with subcutaneous fat in several ways. Usually, HFs encompassed by subcutaneous fat cells and the dermis shape an interfollicular dermal macro-environment, which is imperative for maintaining the best possible growth of bulge and follicle cells. (Source - 1)
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There was a significant increase in hair diameter and density of patients with androgenetic alopecia (AGA) who were injected with autologous adipose tissue (AT) in a single session. (Source - 1)
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After one session of autologous fat transplantation (AFT), not only was there an expected improvement in the area of atrophy but also hair regrowth was observed in the alopecic lesion three months after the fat transfer. (Source - 1, 2)
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Patientes with AGA treated with topical adipose-derived stem cell constituent extract [ADSC-CE] (Source - 1)
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Adipocytes emit BMP2 during the late anagen to the middle of the telogen stage, which supports the resting state of hair follicle stem cells (HFSCs) in the niche; however, the emission of BMP2 is lessened toward the late telogen stage, which bolsters the activation of HFSCs. Adipocytes, thus, have a critical role in extending the anagen stage (Source - 1)
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Restoration of Subcutaneous Fat - omega 3 fish oils, EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acids) along with other nutrients (capsaicin, resveratrol, curcumin, green tea, etc.) have been associated with the activation of brown fat activity (and browning of white adipose tissue) [Source - 1]
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Adipocyte precursor cells express platelet-derived growth factor (PDGF) alpha to activate the PDGF receptor in the dermal papilla (DP), resulting in hair germ activation. (Source - 1)
Pathways
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miRNA – miR-218-5p – plays an important role in regulating the pathway involved in follicle regeneration (Source - 1)
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When an embryo forms, something akin to a series of messages shoots back and forth between the epidermal layer of the skin and the mesenchyme, or the skin’s connective tissue. These signals spur the creation of hair follicles, a process known as morphogenesis, where an organism’s cells come together to form the body’s organs and tissues (Source - 1)
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Regulation of the hair cycle involves multiple, incompletely understood endocrine, autocrine and paracrine signalling pathways in complex interplay. Of particular note is the Wnt family, and specific roles of members of this family are still to be elaborated. Beta-catenin is a core factor of the Wnt signalling pathway and an essential enabler of stem cell differentiation into follicular keratinocytes (Source - 1)
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DP cell-exosomes, isolated from healthy human scalp specimens, accelerated the onset of anagen and delayed catagen in mouse models, resulting in increased levels of β-catenin and Sonic hedgehog (Shh). (Source - 1)
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Human dermal papillae exposed to activated human dermal fibroblasts (hDFs) produce stimulated extracellular vesicles (st-EVs) that secrete the non-Wnt ligand Norrin. It is hypothesised that subsequent activation of the β-catenin pathway is enhanced by hDF-provided Frizzled-4 (Fzd4), the specific receptor for Norrin, resulting in the identified enhanced hair follicle growth ex vivo. (Source - 1)
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Hair regrowth with topical application of valproic acid to C3H mice. Unlike minoxidil, valproic acid was found to activate the Wnt/β-catenin pathway. Other inducers of the Wnt/β-catenin pathway, including 4-phenyl butyric acid (PBA), lithium chloride and beryllium chloride, were also investigated and found to stimulate hair regrowth in vivo. (Source - 1)
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Alpinetin (AP), a compound extracted from Fabaceae and Zingiberaceae herbs is effective in in promoting hair regeneration by activating HFSCs via Wnt signaling. (Source - 1)
CRISPR Gene Editing
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Experimental drug SM04554 focuses on stopping hair loss and regrowing existing hair follicles through the Wnt pathway of the scalp. The Wnt pathway is a protein pathway that regulates hair growth by passing signals through surface cell receptors. When the SM04554 is applied to the Wnt pathway, it can keep hair follicles in their anagen (or active growth) phase. The medication can effectively stop hair fall, repair hair follicles, and even increase the number of active hair follicles. (Source - 1)
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In theory, you can treat hair loss permanently by changing your DNA so your body can be less sensitive to DHT. One of the most recent groundbreaking technologies developed is the CRISPR-Cas9 gene editing tool, which can allow you to switch off the genes that make men and women more likely to lose their hair. (Source - 1)
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South Korean biotechnology company Moogene developed a microbubble-nanoliposomal delivery system for androgenic alopecia therapy. They created a sequence of sgRNA or a ‘guide RNA’ to target the SRD5A2 gene, which is responsible for the creation of the 5AR enzyme that converts testosterone into DHT. (Source - 1)
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The gene editing particles of Cas9 and sgRNA are encapsulated into the nanoliposomes attached to microbubbles from a topical solution. Once the topical solution is applied to skin containing hair follicles, the scientists apply a specific ultrasound frequency to the skin that bursts the microbubbles and creates an entrance in the skin’s surface. Through this cavity, the nanoliposomes are transported past the epidermis and into the dermal papilla cells. (Source - 1)
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Once the Cas9 protein enters the dermal papillae, it acts as the scissors cutting through the native RNA and allows the crafted sgRNA sequence to stop the 5AR gene. A patient who undergoes this procedure would no longer be sensitive to DHT. (Source - 1)
Miscellaneous
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The dermal papilla (DP) of the hair follicle is both a chemical and physical niche for epithelial progenitor cells that regenerate the cycling portion of the hair follicle and generate the hair shaft. DP plays a key role in specifying the size, shape, and color of the hair as well as the frequency with which it regenerates. (Source - 1)
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EDAR is a major genetic determinant of Asian hair thickness (Source - 1)
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Androgenetic alopecia (AGA), also known as male pattern baldness, is associated with androgen and androgen receptor (AR) signaling. Nuclear localization of AR is elevated in the dermal papilla (DP) of balding scalp in patients with AGA. Blood vessels regress in the DP of balding scalp at the early stage of hair follicle miniaturization in AGA development. (Source - 1)
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VEGF (vascular endothelial growth factor) is a major mediator of hair follicle growth and cycling and provide the first direct evidence that improved follicle vascularization promotes hair growth and increases hair follicle and hair size. Transgenic overexpression of VEGF in outer root sheath keratinocytes of hair follicles strongly induced perifollicular vascularization, resulting in accelerated hair regrowth after depilation and in increased size of hair follicles and hair shafts. Conversely, systemic treatment with a neutralizing anti-VEGF antibody led to hair growth retardation and reduced hair follicle size. (Source - 1)
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Skin tissue regeneration after injury involves the production and integration of signals by stem cells residing in hair follicles (HFSCs). TSLP is produced in the skin in response to injury. Stem cells in hair follicles mobilize after injury and aid regeneration of hair follicles, sebaceous glands, and the epidermis. TSLP is sufficient to initiate hair cycle activation in quiescent hair follicles and accelerate hair growth after wounding. [Source - 1]
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Sulphur rich compounds with anti-inflammatory properties to strengthen the the keratin in hair and influence hair growth (extend the anagen phase and shortens the resting phase) [Sources - 1,2, 3]
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Balanced levels of TGF-β (one of the small proteins called cytokines and helps the immune system and blood cells moderate the hair follicle growth cycle) [Source - 1, 2]
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TGF-beta extends its work to the cells inside hair follicles. It helps activate some hair follicle cells to produce new life, and later, it helps orchestrate apoptosis, the process of cell death. With just the right amount of TGF-beta, cell division is activated, stimulating growth of the follicle. But if too much is present, it tips the cells into apoptosis, leading to loss of hair follicles and, as a result, baldness. [Source - 1]
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Telomerase reverse transcriptase (TERT) overexpression in skin activates resting hair follicle bulge stem cells, which triggers initiation of a new hair follicle growth phase and promotes hair synthesis. Polyphenols (resveratrol and fisetin) that activate TERT expression in keratinocytes, and identified resveratrol and fisetin as strong hTERT-augmenting compounds, also regulated the gene expression of cytokines such as IGF-1 and KGF, which activate the β-catenin pathway, and TGF-β1, which plays an important role in maintaining the niche of hair follicle stem cells, thus are thought to play roles in promoting hair growth. These polyphenols, especially fisetin, promoted hair growth from the shaved dorsal skin of mice, which suggests that these polyphenols activate the transition from telogen to anagen phase. [Source - 1]
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A variant of the protein osteopontin — a naturally occurring molecule in our bodies — could increase hair growth in mice. Subsequent studies found that this protein variant has a very specific target on hair follicle cells and can accelerate the hair cycle from resting to growth phases. (Source - 1)
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Hepatocyte growth factor/scatter factor has been shown to stimulate hair follicle growth in vitro, and insulin-like growth factor 1 (IGF-1) has been identified as a significant regulator in the hair follicle. (Source - 1)
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Lymphatic vessels (LVs) have been shown to localise adjacent to the bulge, with increased density and absence respectively in transgenic mice associated with prolonged anagen or accelerated entry into catagen. Furthermore, LV-promoting VEGF-C injections have been shown to promote hair follicle growth in mice. (Source - 1)
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Adipose-derived stem cells. Mesenchymal stem cells, rich in adipose tissue (ADSCs), are multipotent cells that influence surrounding cells through the generation of growth factors and have demonstrated a capacity to promote hair growth in vitro and in vivo. (Source - 1)
Alternate treatments
- Inaudible sound at 30 kHz promoted the proliferation of hair follicle cells and that this effect inhibited hair loss signals induced by DHT (Source - 1)
Low Level Laser Therapy
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Photobiomodulation (PBM), also called low level laser therapy (LLLT), is a treatment used to stimulate hair follicles to grow. Results indicated that low-level laser therapy (LLLT) with a 830-nm wavelength resulted in greater stimulation of hair growth than the other wavelengths examined and 785 nm also showed a significant effect on hair growth. (Source - 1 2)
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Low-level laser therapy (LLLT) is occasionally synonymous with red light therapy, cold laser and soft laser. It is thought to exert a biomodulation/biostimulation effect on tissue, promoting anti-inflammatory effects. The exact mechanism of action in stimulating hair regrowth is not known. Improved cellular activity, reduced inflammation and improved microcirculation may be involved. The therapeutic effects are delivered in wavelengths ranging from 500 to 1100 nm (red to near infrared) at low energy density (3 to 90 mW/cm2) (Source - 1)
Electric Simulation
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Electric stimulation can induce hair growth by stimulating follicles that are phasing out to become reinvigorated, possibly through regulation of multiple hair growth factors in the scalp. (Source - 1)
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Electrotherapy, also known as Electro Tricho Genesis, has proven to be an attractive non- surgical and non-invasive treatment in reversing male-patterned baldness and other hair loss problems in both men and women. (Source - 1)
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PEF (pulsed electric fields) shifted hair follicles from resting telogen to active anagen, and voltage was the most influential parameter. A single treatment at 270V, 300pulses, and 270us pulse length, lead to a 5.05-fold increase in anagen follicles at treated sites. (Source - 1)
PRP Treatment
- Jing and Plasma directly targeted to scalp for PRP treatment
- Automated dermaroller + minoxidil + finasteride / dutasteride to the scalp with no side effects like low libido, ED problems, depression, suicidal tendencies etc from anything
Traditional
Intercession
- Help from beings and entities - left to Captain
- Automated scalp massage, cooling of scalp with the effect of cold feeling of mint (but not the actual application of mint)
- Automated blood circulation and stimulation of Scalp exercies by Tom Hagerty
- Enveloped in the abundance of thick, voluminous hair with best hair density possible (3000 to 5000 strands per square inch) [Source - 1]
Nutrients & Supplements
Agents improving blood supply to the scalp
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Niacin (vitamin B3)
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Vitamin B complex
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Ascorbic acid (vitamin C)
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Tocopherol (vitamin E)
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Grape seed
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Rosemary oil
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Sage
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Nettles
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Hibiscus rosasinensis
(Source - 1) -
Agents improving hair texture and thus preventing loss of dry brittle hairs - Essential fatty acids (primrose and salmon oil)
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Amino acids (l-cysteine and l-methionine)(Source - 1)
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